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Jennifer Lopez may have just given birth, but she's all in favor of Plan B.

After taking time off her busy film career to play mama to fraternal twins Emme and Max (born last February), the A-lister has signed on to topline a fertility-themed romantic comedy for CBS Films.

Per Variety, Lopez will play a single woman who, unlucky in love, resorts to artificial insemination to have a child only to wind up falling for Mr. Right on the day she learns she's pregnant.

Plan B, written by Kate Angelo, is slated to start shooting in April or May. Also in the pipeline for 2009, J.Lo is attached to star in The Governess, playing a thief who poses as a nanny to a wealthy widower in order to pull off the job of a lifetime.

Hot off her holiday hit, Four Christmases, Reese Witherspoon has come aboard to play the lead in an untitled comedy from As Good As It Gets director James L. Brooks. The plot is being kept tightly under wraps but the flick is supposedly an ensemble along the lines of the helmer's earlier classics, Broadcast News and Terms of Endearment. Lensing starts in March.